They are derived from phosphoric acids
and form two series of compounds known as alkyl phosphates, and aryl phosphates
- These
are basically chemical insecticides and used to prevent agricultural
products but when ingested by humans adversely affect health or may become
life–threatening.
- Fatal
dose: TEPP 50 mg IM or 100 mg orally/OMPA 80 mg IM or 175 mg
orally/Parathion 80 mg IM or 175 mg orally/HETP 60 mg IM or 350 mg
orally/Malathion and diazinon 1g orally
- The
fatal period is usually within 24 hours in untreated cases and within 10
days in those treated cases when treatment is not successful. In non–fatal
cases, the acute effect lasts for 6 to 30 hours which disappear in 2 to 3
days but may sometime persist for 2 weeks. Complete recovery occurs in 10
days in patients treated early.
- Atropine
is the antidote.
- Cause
of death is by paralysis of respiratory muscles, respiratory arrests due
to failure of respiratory centre or intense bronchi constriction resulting
in respiratory failure.
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