Coffee consumption is
inversely related to the risk of cirrhosis or hepatocellular carcinoma (HCC).
However, the protective effect of coffee drinking against the risk of HCC was
not established in HBV-prevalent region.
A hospital-based
case–control study was performed in 1364 subjects. A total of 258 HCC patients,
480 health-check examinees (control 1, HCE) and 626 patients with chronic liver
disease other than HCC (control 2, CLD) were interviewed on smoking, alcohol
and coffee drinking using a standardized questionnaire. HBV e-antigen (HBeAg)
status and serum HBV DNA levels were measured in patients infected with HBV.
After adjustment for age, gender, obesity, DM, presence of hepatitis virus (except for HCE) and lifetime alcohol drinking/smoking, a high lifetime coffee consumption (≥20 000 cups) was an independent protective factor against HCC, in each analyses using healthy and risky control groups respectively.
After adjustment for age, gender, obesity, DM, presence of hepatitis virus (except for HCE) and lifetime alcohol drinking/smoking, a high lifetime coffee consumption (≥20 000 cups) was an independent protective factor against HCC, in each analyses using healthy and risky control groups respectively.
However, the high
coffee consumption did not affect the HCC risk in patients with HBV after
adjustment for HBeAg status, serum HBV DNA level and antiviral therapy.
A high lifetime coffee consumption was negatively associated with a HCC development. However, this difference of coffee exposure with the HCC group was reduced in chronic hepatitis B patients by the dominant role of viral replication (Liver International 2013;33(7):1092-1099).
A high lifetime coffee consumption was negatively associated with a HCC development. However, this difference of coffee exposure with the HCC group was reduced in chronic hepatitis B patients by the dominant role of viral replication (Liver International 2013;33(7):1092-1099).
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