The Risk and Prevention Study enrolled patients with multiple
cardiovascular risk factors or known vascular disease and, after a
median follow–up of five years, found no reduction in coronary heart
disease death with n–3 polyunsaturated fatty acid supplementation
compared with placebo.
This result contrasts with early trials of fish oil but is consistent with more recent studies. Additional large trials with long–term follow–up are needed to clarify whether n-3 fatty acid supplementation might have different effects on cardiac mortality depending on whether patients are also receiving aggressive treatment for primary or secondary prevention of CHD (Source Uptodate)
This result contrasts with early trials of fish oil but is consistent with more recent studies. Additional large trials with long–term follow–up are needed to clarify whether n-3 fatty acid supplementation might have different effects on cardiac mortality depending on whether patients are also receiving aggressive treatment for primary or secondary prevention of CHD (Source Uptodate)
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